Prognostic value of Dickkopf-1 and ß-catenin expression in advanced gastric cancer
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چکیده
منابع مشابه
Evaluation of the Prognostic Value and TRIP13 gene Expression in Gastric Cancer
Introduction: Gastric cancer is a major public health issue worldwide. The factors that initiate cancer are not well understood, however aberrant expression of genes is associated with this cancer. TRIP13 plays pivotal roles in meiotic recombination, DNA repair, and cell cycle progression. An increasing body of evidence suggests that TRIP13 may possess functions other than meiosis and mitosis, ...
متن کاملDickkopf-1 Expression Is a Novel Prognostic Marker for Gastric Cancer
AIM To investigate the involvement of Dickkopf-1 expression in gastric cancer. METHODS Dickkopf-1 mRNA and protein expression were determined by real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and immunohistochemistry in specimens of primary cancer and their adjacent noncancerous tissues in gastric cancer patients. RESULTS Dickkopf-1 mRNA and protein express...
متن کاملPrognostic value of alcohol dehydrogenase mRNA expression in gastric cancer
Previous studies have reported that alcohol dehydrogenase (ADH) isoenzymes possess diagnostic value in gastric cancer (GC). However, the prognostic value of ADH isoenzymes in GC remains unclear. The aim of the present study was to identify the prognostic value of ADH genes in patients with GC. The prognostic value of ADH genes was investigated in patients with GC using the Kaplan-Meier plotter ...
متن کاملPrognostic value of sonic hedgehog protein expression in gastric cancer.
OBJECTIVE Sonic hedgehog is produced in gastric epithelial cells and plays a crucial role in parietal cell function and the regulation of gastric epithelial cell differentiation. Emerging evidence suggests that the sonic hedgehog pathway is not only involved in the development of cancers but also in their progression and aggressiveness. METHODS To assess its prognostic value in gastric cancer...
متن کاملClinical significance and prognostic value of serum Dickkopf-1 concentrations in patients with lung cancer.
BACKGROUND Dickkopf-1 (DKK1), a secreted protein, is known as a negative regulator of the Wnt signaling pathway, which has been implicated in the development of several types of cancers. Clinical significance of serum DKK1 in lung cancer remains to be determined. METHODS A novel time-resolved immunofluorometric assay was developed. By use of this method, we investigated the serum concentratio...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2018
ISSN: 1471-2407
DOI: 10.1186/s12885-018-4420-8